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(CIT): Research in the Dr. Wilson's laboratory focuses on the study of information representation across large populations of neurons in the mammalian nervous system, as well as on the mechanisms that underlie formation and maintenance of distributed memories in freely behaving animals. To study the basis of these processes, his lab employs a combination of molecular genetic, electrophysiological, pharmacological, behavioral, and computational approaches. These studies of learning and memory in awake, behaving animals have led to the exploration of the nature of sleep and its role in memory. Previous theories have suggested that sleep states may be involved in the process of memory consolidation, in which memories are transferred from short to longer-term stores and possibly reorganized into more efficient forms. Recent findings have identified explicit correlates of dreaming during periods of REM sleep allowing examination of dream content as it relates to memory. Experiments involving simultaneous monitoring of areas in the hippocampus and neocortex demonstrated coordinated activity between the hippocampus and the cortex during both awake and sleep states. Taken together, simultaneous monitoring of memory patterns in the hippocampus and neocortex has allowed us to study the differences between these structures in how memories are formed. They have found evidence that the neocortex may be creating memories that attempt to generalize across experience, while the hippocampus stores the experiences themselves.
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Video Length: 5251
Date Found: September 16, 2008
Date Produced:
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NIH |
November 19, 2008
(CIT): The Mitochondria Interest Group (MIG) is an Inter-Institute Interest Group at the National Institutes of Health (NIH), with members from NIH and from around the world! MIG is concerned with all aspects of the mitochondrion and diseases in which the mitochondrion is involved. For more ...
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NIH |
November 19, 2008
(CIT): Transcriptional interactions in the cell are modulated by a variety of mechanisms that prevent their representation as pairwise interactions between a transcription factor and its targets. These include, among others, transcription factor modification by phosphorylation and acetylation, ...
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NIH |
November 19, 2008
(CIT): Dr. Greene received her PhD from the University of Texas Medical Branch at Galveston, where her research focused on determinants of alphavirus virulence, using Venezuelan equine encephalitis virus as a model system. She is presently a postdoctoral fellow in Dr. Diane Griffins lab at Johns ...
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NIH |
November 19, 2008
(CIT): The SBIG is a clearinghouse for discussions and interactions between scientists interested in all aspects of molecular structure, from experimental determination by x-ray crystallography, electron microscopy, mass spectrometry, and NMR, to theoretical and computational biology and ...
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NIH |
September 17, 2008
(CIT): NIH Clinical Center Ethics Grand Rounds A researcher from the US working in an international setting discovered genetic information that could have a significant impact on reproductive decision-making. When exploring how to handle this information he was told by local researchers, "We ...
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