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(CIT): Neurotransmitters, hormones, and pharmacologic agents act by binding specific receptors on the cell surface. Dr. Clapham's lab is interested in how a receptor initiates intracellular events such as the opening of ion channels, the activation of enzymes, or the release of intracellular calcium; and the structures, functions, and relations of receptors, G proteins, ion channels, and calcium. The transient receptor potential (TRP) superfamily comprises a group of non-selective cation channels that sense and respond to changes in their local environments. TRP channels are found in many eukaryotes, from yeast to mammals. They are a diverse group of proteins organized into six families. In the peripheral nervous system, stimuli including temperature, pressure, inflammatory agents, and receptor activation effect TRP-mediated responses.
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Video Length: 0
Date Found: September 17, 2008
Date Produced:
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NIH |
November 19, 2008
(CIT): The Mitochondria Interest Group (MIG) is an Inter-Institute Interest Group at the National Institutes of Health (NIH), with members from NIH and from around the world! MIG is concerned with all aspects of the mitochondrion and diseases in which the mitochondrion is involved. For more ...
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NIH |
November 19, 2008
(CIT): Transcriptional interactions in the cell are modulated by a variety of mechanisms that prevent their representation as pairwise interactions between a transcription factor and its targets. These include, among others, transcription factor modification by phosphorylation and acetylation, ...
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NIH |
November 19, 2008
(CIT): Dr. Greene received her PhD from the University of Texas Medical Branch at Galveston, where her research focused on determinants of alphavirus virulence, using Venezuelan equine encephalitis virus as a model system. She is presently a postdoctoral fellow in Dr. Diane Griffins lab at Johns ...
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NIH |
November 19, 2008
(CIT): The SBIG is a clearinghouse for discussions and interactions between scientists interested in all aspects of molecular structure, from experimental determination by x-ray crystallography, electron microscopy, mass spectrometry, and NMR, to theoretical and computational biology and ...
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NIH |
September 17, 2008
(CIT): NIH Clinical Center Ethics Grand Rounds A researcher from the US working in an international setting discovered genetic information that could have a significant impact on reproductive decision-making. When exploring how to handle this information he was told by local researchers, "We ...
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