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Prof Workman talks to ecancertv at the 2010 San Antonio Breast Cancer Symposium, explaining what molecular chaperones are and their role in causing cancer. He discusses the first generation of Hsp90 (Heat Shock Protein 90) inhibitors and the ICR’s creation of a 2nd generation of Hsp90 inhibitors, e.g.  NVP-AUY922, currently in a phase II trials. Prof Workman also looks to the future of the 3rd generation of Hsp90 inhibitors. A recent phase I trial has also discovered a clear clinical link between ErbB-2 (HER2/neu ) positive breast cancer and regression after treatment with an Hsp90 inhibitor (for patients that have become refractory to Herceptin (trustuzamab). Toxicities are also covered.
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Video Length: 0
Date Found: January 19, 2011
Date Produced:
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 www.ecancer.tv |
March 01, 2011
Prof Mathias Rummel discusses his research demonstrating the efficacy of bendamustine plus rituximab as a treatment for mantle cell lymphomas (MCL). Following the results presented at ASH 2009 revealing the superiority of bendamustine plus rituximab over CHOP plus rituximab as first line ...
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 www.ecancer.tv |
March 01, 2011
The panel discuss how the results of recent clinical trials have advanced our understanding of the optimal treatment for multiple myeloma. The development of new combinations containing drugs such as thalidomide, bortezomib and lenalidomide is helping clinicians achieve complete remission and ...
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 www.ecancer.tv |
March 01, 2011
Prof Mathias Rummel talks about the history of bendamustine from its origins in 1960’s East Germany to the modern trials evaluating the use of bendamustine and rituximab to treat lymphoproliferative diseases.
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 www.ecancer.tv |
March 01, 2011
Prof Antonio Palumbo and Prof Vincent Rajkumar discuss some of the key research into myeloma that was presented at ASH 2010. This includes trials demonstrating that post transplant lenalidomide maintenance treatment dramatically improves progression free survival, a study comparing bortezomib ...
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 www.ecancer.tv |
February 23, 2011
Prof Anton Hagenbeek discusses the five and a half year results of the First-Line Indolent Trial (FIT) study. The randomised phase III FIT study evaluates the clinical benefits and safety of a single infusion of Zevalin (ibritumomab tiuxetan) in patients with previously untreated follicular ...
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