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Dr William Wierda speaks about his work developing a treatment for patients with chronic lymphocytic leukaemia (CLL) that are refractory to standard therapies. Patients were divided into those refractory to fludarabine and alemtuzumab and those refractory to fludarabine with bulky lymph nodes, and were treated with the human CD20 monoclonal antibody ofatumumab. The trial demonstrated that ofatumumab can be used as a safe effective monotherapy for these patient populations. Dr Wierda explains how the patient groups were defined, what treatment regimen they received, outlines the adverse effect that were encountered and discusses how this treatment may be incorporated in first line CLL treatment.
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Video Length: 0
Date Found: February 13, 2011
Date Produced:
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 www.ecancer.tv |
March 01, 2011
Prof Mathias Rummel discusses his research demonstrating the efficacy of bendamustine plus rituximab as a treatment for mantle cell lymphomas (MCL). Following the results presented at ASH 2009 revealing the superiority of bendamustine plus rituximab over CHOP plus rituximab as first line ...
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 www.ecancer.tv |
March 01, 2011
The panel discuss how the results of recent clinical trials have advanced our understanding of the optimal treatment for multiple myeloma. The development of new combinations containing drugs such as thalidomide, bortezomib and lenalidomide is helping clinicians achieve complete remission and ...
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 www.ecancer.tv |
March 01, 2011
Prof Mathias Rummel talks about the history of bendamustine from its origins in 1960’s East Germany to the modern trials evaluating the use of bendamustine and rituximab to treat lymphoproliferative diseases.
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 www.ecancer.tv |
March 01, 2011
Prof Antonio Palumbo and Prof Vincent Rajkumar discuss some of the key research into myeloma that was presented at ASH 2010. This includes trials demonstrating that post transplant lenalidomide maintenance treatment dramatically improves progression free survival, a study comparing bortezomib ...
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 www.ecancer.tv |
February 23, 2011
Prof Anton Hagenbeek discusses the five and a half year results of the First-Line Indolent Trial (FIT) study. The randomised phase III FIT study evaluates the clinical benefits and safety of a single infusion of Zevalin (ibritumomab tiuxetan) in patients with previously untreated follicular ...
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