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(CIT): Dr. Ashe's research addresses the molecular basis of memory loss and cognitive dysfunction in Alzheimer's disease. The studies involve the creation of transgenic mouse models of Alzheimer's disease in order to understand how the amyloid-[beta] and tau proteins impair memory and cognition. The work has shown that the aggregates of amyloid-[beta] and tau proteins which define Alzheimer's disease neuropathologically do not cause cognitive deficits in mice. These investigations have led to the discovery of a form of the amyloid-[beta] protein called A[beta] star (A[beta]*) that disrupts cognitive function in mice and rats, and revealed a potential mechanism by which interactions with a neuronal receptor may impair memory.
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Video Length: 3863
Date Found: September 16, 2008
Date Produced:
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![Mitochondrial porin deficient mice : a murine model of Mendelian respiratory chain defects and encephalopathy [electronic resource] / Fernando Scaglia. | BahVideo.com](http://stc.bahvideo.com/com/img/thumbs/2306328.jpg) NIH |
November 19, 2008
(CIT): The Mitochondria Interest Group (MIG) is an Inter-Institute Interest Group at the National Institutes of Health (NIH), with members from NIH and from around the world! MIG is concerned with all aspects of the mitochondrion and diseases in which the mitochondrion is involved. For more ...
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![Genome-wide discovery of post-translational modulators of transcriptional interactions in human B lymphocytes [electronic resource] / Andrea Califano. | BahVideo.com](http://stc.bahvideo.com/com/img/thumbs/5595301.jpg) NIH |
November 19, 2008
(CIT): Transcriptional interactions in the cell are modulated by a variety of mechanisms that prevent their representation as pairwise interactions between a transcription factor and its targets. These include, among others, transcription factor modification by phosphorylation and acetylation, ...
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![Bioluminescence imaging of alphavirus encephalitis in mice : a mechanism for therapeutic screening [electronic resource] / Ivy Greene. | BahVideo.com](http://stc.bahvideo.com/com/img/thumbs/1303093.jpg) NIH |
November 19, 2008
(CIT): Dr. Greene received her PhD from the University of Texas Medical Branch at Galveston, where her research focused on determinants of alphavirus virulence, using Venezuelan equine encephalitis virus as a model system. She is presently a postdoctoral fellow in Dr. Diane Griffins lab at Johns ...
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![Protein-protein interactions--what is the preferred way for proteins to interact? [electronic resource] / Ozlem Keskin and Ruth Nussinov. | BahVideo.com](http://stc.bahvideo.com/com/img/thumbs/10061587.jpg) NIH |
November 19, 2008
(CIT): The SBIG is a clearinghouse for discussions and interactions between scientists interested in all aspects of molecular structure, from experimental determination by x-ray crystallography, electron microscopy, mass spectrometry, and NMR, to theoretical and computational biology and ...
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![Genetics research in the international setting [electronic resource] / Max Muenke and Kaare Berg. | BahVideo.com](http://stc.bahvideo.com/com/img/thumbs/9224416.jpg) NIH |
September 17, 2008
(CIT): NIH Clinical Center Ethics Grand Rounds A researcher from the US working in an international setting discovered genetic information that could have a significant impact on reproductive decision-making. When exploring how to handle this information he was told by local researchers, "We ...
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